IAP (Integrin-Associated Protein)
نویسندگان
چکیده
منابع مشابه
Expression and Function of Integrin Associated Protein (iap)/cd47 in Human Articular Cartilage
Background: Integrin-associated protein (IAP) /CD47, a member of immunoglobulin super family (IgSF), is expressed in a variety of cell types. In the present work, the expression pattern of IAP/ CD47 in normal and osteoarthritis (OA) human articular cartilage and its role in mechanotransduction pathway following mechanical stimulation have been studied. Methods: Using immunohistochemistry and st...
متن کاملMembrane mobility and clustering of Integrin Associated Protein (IAP, CD47)--major differences between mouse and man and implications for signaling.
Integrin Associated Protein (IAP, CD47) is a ubiquitous integral membrane protein implicated in processes (in mice) that range from inhibiting clearance by phagocytes [Oldenborg et al., Science 2000; Gardai et al., Cell 2005] to neutrophil motility [Lindberg et al., Science 1996]. SIRPalpha is CD47's main receptor on phagocytes plus a number of other cell types, and SIRPalpha-CD47 interactions ...
متن کاملIntegrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis.
RATIONALE The ICAP1 (integrin cytoplasmic domain-associated protein-1) is a specific intracellular binding protein of beta1-integrins and the cerebral cavernous malformation (CCM) protein CCM1. ICAP1 recruits CCM1 to the cell membrane and activates CCM1 by changing its conformation. Because CCM1 plays a critical role for cardiovascular development, we hypothesized that its activator ICAP1 is in...
متن کاملTransendothelial migration of neutrophils involves integrin-associated protein (CD47).
Inflammation is a primary pathological process. The development of an inflammatory reaction involves the movement of white blood cells through the endothelial lining of blood vessels into tissues. This process of transendothelial cell migration of neutrophils has been shown to involve neutrophil beta 2 integrins (CD18) and endothelial cell platelet-endothelium cell adhesion molecules (PECAM-1; ...
متن کاملThrombospondin Modulates OLv~ 3 Function through Integrin-associated Protein
Integrin-associated protein (IAP) is a receptor for the carboxyl-terminal "cell-binding domain" (CBD) of thrombospondin 1 (TS1). lAP associates with av[33 integrin and mAbs against lAP inhibit certain integrin functions. Here we examine the effects of the TS1 CBD and 4N1K (KRFYVVMWKK), a cell-binding peptide derived from it, on the adhesion and spreading on vitronectin (VN) of C32 human melanom...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 1998
ISSN: 1880-8808,0915-7441
DOI: 10.2491/jjsth.9.201